John Sen Trescot (d. ca. 1821), physician, was described as a resident of Charleston, South Carolina, when he entered the freshman class of Yale College in 1804. He did not graduate. In 1810 Trescot received a medical degree from the University of Pennsylvania, and he practiced medicine in Charleston for at least a decade starting by 1809. He was a founder of the Antiquarian Society of Charleston in 1813, and he sometimes served as an attending physician at the city dispensary. Trescot owned fourteen slaves in 1820 (Catalogue Of the Officers and Students in Yale-College, November, 1804 [n.d.]; Directory for the District of Charleston [Charleston, 1809], 102; Pennsylvania Magazine of History and Biography 31 [1907]: 380–1; Charleston City Gazette and Commercial Daily Advertiser, 5 Oct. 1810, 6 Oct. 1812, 25 Oct. 1821; Joseph Folker, A Directory of the City and District of Charleston; and Stranger’s Guide … for the year 1813 [Charleston, 1813], 78; The Directory and Stranger’s Guide, for the City of Charleston … For the Year 1819 [Charleston, 1819], 91; John L. E. W. Shecut, Shecut’s Medical and Philosophical Essays [Charleston, 1819], 48; DNA: RG 29, CS, S.C., Charleston Co., 1820).

On this day Trescot sent a similar letter to President James Madison (Madison, Papers description begins William T. Hutchinson, Robert A. Rutland, John C. A. Stagg, and others, eds., The Papers of James Madison, 1962– , 31 vols.  Congress. Ser., 17 vols.  Pres. Ser., 6 vols.  Sec. of State Ser., 8 vols description ends , Pres. Ser., 6:601).